Treatments targeting inotropy
نویسندگان
چکیده
منابع مشابه
Cardiac α1-Adrenoceptors and Inotropy
Cardiac α1-adrenoceptor stimulation elicits a positive inotropic effect because of myofilament Ca2+ sensitization with a small increase in Ca2+ transients predominantly mediated by α1B-adrenoceptors via the intracellular alkalinization and potential myosin light chain 2 phosphorylation. However, the α1-adrenoceptor– mediated inotropy exhibits a wide range of species-dependent variation. In addi...
متن کاملCardiac α1-Adrenoceptors and Inotropy
Cardiac α1-adrenoceptor stimulation elicits a positive inotropic effect because of myofilament Ca2+ sensitization with a small increase in Ca2+ transients predominantly mediated by α1B-adrenoceptors via the intracellular alkalinization and potential myosin light chain 2 phosphorylation. However, the α1-adrenoceptor– mediated inotropy exhibits a wide range of species-dependent variation. In addi...
متن کاملCardiac α1-Adrenoceptors and Inotropy
Cardiac α1-adrenoceptor stimulation elicits a positive inotropic effect because of myofilament Ca2+ sensitization with a small increase in Ca2+ transients predominantly mediated by α1B-adrenoceptors via the intracellular alkalinization and potential myosin light chain 2 phosphorylation. However, the α1-adrenoceptor– mediated inotropy exhibits a wide range of species-dependent variation. In addi...
متن کاملEmerging treatments in lung cancer – targeting the RLIP76 molecular transporter
Multidrug resistance in lung cancer cells is a significant obstacle in the treatment of lung cancer. Resistance to chemotherapeutic agents is often the result of efflux of the drugs from cancer cells, mediated by adenosine triphosphate (ATP)-dependent drug transport across the plasma membrane. Thus, identifying molecular targets in the cancer cell transport machinery could be a key factor in su...
متن کاملCardiac Glycoside Receptors and Positive Inotropy
With Contributions by L .Brown, W.H.Barry , D.Charlemagne, E. Erdmann, A . A . L.Fox, U.Fricke, W.H.van Gilst, T.Godfraind, K.Greeff, M.Heller , Κ.-Ο. Haustein, G. Isenberg, R.Jacob, T.Kazazoglou, D . K i m , K.Kochsiek, J .M.Koomen, W.Krawietz, M.Lazdunski, L.G.Lelievre, H.Lül lmann, P.Mansicr, E.Noack, D.Noble, D.Palm, Th.Peters, H.-H.Pri l lwitz , J.F.Renaud, B.Rossi, J . A . M . Schevers, T...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Heart Journal
سال: 2018
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/ehy600